Denisovan EPAS1 in Modern Tibetans: A Genetic Lifeline
Introgressed EPAS1 variant optimizes oxygen use at altitude without dangerous blood thickening.
Dorje Namgyal
Genetic studies show Tibetans inherited a Denisovan-derived EPAS1 haplotype that modulates hypoxia responses, enabling healthy life at extreme elevations.
Physiology
Balanced erythropoiesis prevents excessive hematocrit, reducing risks of thrombosis and chronic mountain sickness.
Population Genetics
Signals of selection around EPAS1 correlate with highland populations; lowland groups lack the variant’s frequency.
FAQs
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